The Nintendo 64, stylized as NINTENDO64 and often referred to as N64, is Nintendo's third home video game console for the international market. Named for its 64-bit central processing unit, it was released in June 1996 in Japan, September 1996 in North America, March 1997 in Europe and Australia, September 1997 in France and December 1997 in Brazil. It is the industry's last major home console to use the cartridge as its primary storage format, although current handheld systems (such as the PlayStation Vita and Nintendo 3DS) also use cartridges. While the Nintendo 64 was succeeded by Nintendo's MiniDVD-based GameCube in November 2001, the consoles remained available until the system was retired in late 2003.
Code named Project Reality, the console's design was mostly finalized by mid-1995, though Nintendo 64's launch was delayed until 1996. As part of the fifth generation of gaming, the system competed primarily with the PlayStation and the Sega Saturn. The Nintendo 64 was launched with three games: Super Mario 64 and Pilotwings 64, released worldwide; and Saikyō Habu Shōgi, released only in Japan. The Nintendo 64's suggested retail price at launch was US$199.99 and it was later marketed with the slogan "Get N, or get Out!". With 32.93 million units worldwide, the console was ultimately released in a range of different colors and designs, and an assortment of limited-edition controllers were sold or used as contest prizes during the system's lifespan. IGN named it the 9th greatest video game console of all time and in 1996, Time Magazine named it Machine of the Year.
Sixtyforce is an emulator that runs Nintendo 64 games. It does this by dynamically translating the code that a Nintendo 64 uses into something your Mac understands. Nearly every part of a Nintendo 64 has been painstakingly recreated entirely out of software to pull off such an amazing feat. You can download it from sixtyforce homepage.
Mupen64Plus is a cross-platform plugin-based N64 emulator which is capable of accurately playing many games. Included are four MIPS R4300 CPU emulators, with dynamic recompilers for 32-bit x86 and 64-bit amd64 systems, and necessary plugins for audio, graphical rendering (RDP), signal co-processor (RSP), and input. There is 1 included OpenGL video plugin, called RiceVideo. You can download v2.5 OS X port and plugins from Mupen github download page. As Mupen is command line emulator, You can download a m64py GUI from here.
OpenEmu experimental also emulates Nintendo 64. You can find more info on OpenEmu homepage and download the latest version from here.